Been there on my way to Perito Moreno.
Before and after that I traveled to Puerto Natales in Chile (from which you can see Torres del Paine, or go to Punta Arenas).

In El Calafate you will find an airport, if you need to get there by plane. The only reliable airline serving it is Aereolinas Argentina. (when we where there they where on strike).

On Town, eat at Mi Viejo restaurant. The slowly roasted Lamb is excellent. Prices are competitive, if not lower than similar restaurants.