One great option is to fly to Florence, as thelookingglass suggests, and then rent a car. Florence can be needlessly expensive in terms of hotels, so what I recommend you do is rent a car and find a place in Tuscanny’s beautiful scenery to stay at. Typically, you can find villas for rent (at very reasonable weekly rates, for instance). We stayed twenty minutes south of Sienna in a remote villa for about a week and drove around Tuscanny, visiting some wineries, lots of little midieval villages and fortresses, and even a natural spa. You can find some really neat little places to eat in some of these top-of-the-hill villages as well, which is great, because you can change it up.

Florence itself certainly has good restaurants as well, and you should consider spending at least one night there, since you’ll be in the area.